The College of Surrey has constructed a synthetic intelligence (AI) mannequin that identifies chemical compounds that promote wholesome ageing — paving the way in which in direction of pharmaceutical improvements that stretch an individual’s lifespan.
In a paper printed by Nature Communication’s Scientific Experiences, a group of chemists from Surrey constructed a machine studying mannequin based mostly on the knowledge from the DrugAge database to foretell whether or not a compound can prolong the lifetime of Caenorhabditis elegans — a translucent worm that shares an identical metabolism to people. The worm’s shorter lifespan gave the researchers the chance to see the affect of the chemical compounds.
The AI singled out three compounds which have an 80 per cent probability of accelerating the lifespan of elegans:
- flavonoids (anti-oxidant pigments present in crops that promote cardiovascular well being),
- fatty acids (similar to omega 3), and
- Organooxygens (compounds that comprise carbon to oxygen bonds, similar to alcohol).
Sofia Kapsiani, co-author of the examine and remaining yr undergraduate pupil on the College of Surrey, mentioned:
“Ageing is more and more being recognised as a set of ailments in fashionable drugs, and we are able to apply the instruments of the digital world, similar to AI, to assist decelerate or shield in opposition to ageing and age-related ailments. Our examine demonstrates the revolutionary capacity of AI to assist the identification of compounds with anti-ageing properties.”
Dr Brendan Howlin, lead creator of the examine and Senior Lecturer in Computational Chemistry on the College of Surrey, mentioned:
“This analysis reveals the ability and potential of AI, which is a speciality of the College of Surrey, to drive vital advantages in human well being.”