In an article showing in Nature Biomedical Engineering, a staff of scientists from the UCLA David Geffen College of Medication and UCLA College of Engineering report real-world outcomes on SwabSeq, a high-throughput testing platform that makes use of sequencing to check hundreds of samples at a time to detect COVID-19. They have been capable of carry out greater than 80,000 assessments in lower than two months, with the check exhibiting extraordinarily excessive sensitivity and specificity.

SwabSeq makes use of sample-specific molecular barcodes to concurrently analyze hundreds of samples for the presence or absence of SARS-CoV-2, the virus that causes COVID-19. SwabSeq was granted FDA Emergency Use Authorization in October and is at present deployed at UCLA in a high-complexity CLIA laboratory, which has carried out over 150,000 assessments since December 2020. SwabSeq is a versatile protocol and might quickly scale up testing for novel pathogens, together with COVID-19 and future rising viruses.

“We have now optimized SwabSeq to prioritize scale and low price, key components which are lacking from present COVID-19 diagnostics,” the authors write.

“These outcomes show the potential of SwabSeq for use for SARS-CoV-2 testing on an unprecedented scale,” stated Dr. Valerie Arboleda, Assistant Professor and lead scientist on the undertaking. “SwabSeq provides a possible resolution to the necessity for population-wide testing to stem the pandemic.” Within the months since, the staff has continued to make use of the check, and as of this date has carried out greater than 150,000 assessments.

The groundbreaking expertise was developed in a collaboration between scientists on the Division of Computational Medication affiliated with each the David Geffen College of Medication and the Samueli College of Engineering at UCLA, the Division of Human Genetics, the Division of Pathology and Laboratory Medication, and Octant, a start-up firm based and incubated at UCLA. SwabSeq is a modification of Octant’s expertise that’s being utilized towards drug discovery and has been made accessible broadly to battle the pandemic. UCLA scientists have been main a broader coalition of educational and industrial labs across the nation and the world to develop the expertise to scale up COVID-19 testing.

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Materials offered by University of California – Los Angeles Health Sciences. Word: Content material could also be edited for fashion and size.

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